Associate Professor Dr. Anton V. Dolzhenko

Contact Details

MSc (Pharmacy), PhD (Medicinal Chemistry)
Associate Professor (Organic and Medicinal Chemistry)

Office: Building 2, Level 5, Room 51
Tel: +603 5514 5867
Fax: +603 5514 6364
Email: anton.dolzhenko@monash.edu

Anton V. Dolzhenko received his degree (with Distinction) in Pharmacy in 2000 and then a PhD degree in Medicinal Chemistry in 2004, both from the Perm State Pharmaceutical Academy (Russia). After that he joined the Pharmacy Department of the National University of Singapore and worked there for 6 years before he moved to the School of Pharmacy, Curtin University (Australia) in 2010 and continued his academic career as a Senior Lecturer. In 2013, he joined the School of Pharmacy, Monash University Malaysia. His current research interests include synthetic and structural aspects of chemistry of nitrogen heterocycles. He has been actively working on the development of new synthetic methods for the preparation of potentially bioactive compounds. His expertise in structural analysis of organic molecules and extensive experience drive Dr Dolzhenko to organize the NMR Campus Infrastructure Platform, which he leads now providing high quality service to internal and external customers.

  1. Adjunct Senior Lecturer, Curtin University, Australia
  2. Member of the Asian Council of Science Editors
  3. Affiliated member of the Publication Integrity and Ethics
  4. Editor-in-Chief of Advances in Chemistry and Biochemistry Sciences
  5. Editorial board member of the following journals:
  • International Journal of Pharmacy
  • American Journal of Organic Chemistry
  • Journal of Crystallography
  • Organic Chemistry: Current Research
  • Chemical Sciences Communications
  • International Research Journal of Pure and Applied Chemistry
  • International Journal of Bioorganic Chemistry & Molecular Biology
  • Mendeleev Journal of Chemistry
  • SOP Transactions on Organic Chemistry
  • International Journal of Drug Discovery and Pharmacy
  • International Journal of Innovation Medicinal Plant Research
  • International Journal of Innovation Pharmacy and Pharmacology
  • Journal of Applied Chemical Science International

RESEARCH INTEREST

  1. Medicinal and organic chemistry
  2. Green chemistry
  3. Heterocyclic chemistry
  4. Microwave-assisted organic synthesis
  5. Multicomponent reactions
  6. Structural and physical organic chemistry
  7. NMR spectroscopy

Refereed Journals and Book Chapters

(* - corresponding author)

  1. Lim, F. P. L.; Luna, G.; Dolzhenko, A. V.* A one-pot, three-component aminotriazine annulation onto 5-aminopyrazole-4-carbonitriles under microwave irradiation. Tetrahedron Lett. 2015, 56(3), 521-524, DOI: 10.1016/j.tetlet.2014.12.010.
  2. Lim, F. P. L.; Dolzhenko, A. V.* 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity. Tetrahedron Lett. 2014, 55(49), 6684-6688, DOI: 10.1016/j.tetlet.2014.10.057.
  3. Lim, F. P. L.; Dolzhenko, A. V.* 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity. Tetrahedron Lett. 2014, in press, DOI: 10.1016/j.tetlet.2014.10.057.
  4. Lim, F. P. L.; Dolzhenko, A. V.* 1,3,5-Triazine-based analogues of purine: from isosteres to privileged scaffolds in medicinal chemistry. Eur. J. Med. Chem. 2014, 85, 371-390, DOI: 10.1016/j.ejmech.2014.07.112.
  5. Lim, F. P. L.; Luna, G.; Dolzhenko, A. V.* A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation. Tetrahedron Lett. 2014, 55(37), 5159-5163, DOI: 10.1016/j.tetlet.2014.07.105.
  6. Dolzhenko, A. V.;* Dolzhenko, A. V. Green solvents for eco-friendly synthesis of bioactive heterocyclic compounds. In: Green Synthetic Approaches for Biologically Relevant Heterocycles, Ed. G. Brahmachari, Elsevier, 2014, pp. 101-139 (ISBN: 978-0-12-800070-0).
  7. Bera, H.; Ojha, P. K.; Tan, B. J.; Sun, L.; Dolzhenko, A. V.; Chui, W. K.; Chiu, G. N. C. Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II. Eur. J. Med. Chem., 2014, 78, 294-303, DOI: 10.1016/j.ejmech.2014.03.063.
  8. Kalinina, S. A.; Elkina, O. V.; Kalinin, D. V.; Syropyatov, B. Ya.; Dolzhenko, A. V.* Diuretic activity and toxicity of some Verbascum nigrum extracts and fractions. Pharm. Biol., 2014, 52(2), 191-198, DOI: 10.3109/13880209.2013.822001.
  9. Sun, L.; Li, J.; Bera, H.; Dolzhenko, A. V.; Chiu, G. N. C.; Chui, W. K. Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors. Eur. J. Med. Chem., 2013, 70, 400-410, DOI: 10.1016/j.ejmech.2013.10.022.
  10. Kalinina, S. A.; Kalinin, D. V.; Dolzhenko, A. V.* A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines. Tetrahedron Lett., 2013, 54(40), 5537-5540, DOI: 10.1016/j.tetlet.2013.07.158.
  11. Dolzhenko, A. V.*; Kalinina, S. A.; Kalinin, D. V. A novel multicomponent microwave-assisted synthesis of 5-aza-adenines. RSC Adv., 2013, 3(10), 15850-15855, DOI: 10.1039/c3ra41932k.
  12. Bera, H.; Dolzhenko, A. V.; Sun, L.; Gupta, S. D.; Chui, W. K. Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors. Chem. Biol. Drug Des., 2013, 82, 351-360, DOI: 10.1111/cbdd.12171.
  13. Bera, H.; Huey, L. M.; Sun, L.; Dolzhenko, A. V.; Chui, W. K. Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones. Bioorg. Chem., 2013, 50, 34-40, DOI: 10.1016/j.bioorg.2013.07.004. – Top 25 hottest articles in the journal (http://top25.sciencedirect.com/subject/chemistry/6/journal/bioorganic-chemistry/00452068/archive/48/)
  14. Bera, H.; Chui, W. K.; Gupta, S. D.; Dolzhenko, A. V.; Sun, L. Synthesis, in vitro evaluation of thymidine phosphorylase inhibitory activity, and in silico study of 1,3,5-triazin-2,4-dione and its fused analogues. Med. Chem. Res., 2013, 22(12), 6010-6021, DOI: 10.1007/s00044-013-0589-1.
  15. Bera, H.; Tan, B. J.; Sun, L.; Dolzhenko, A. V.; Chui, W. K.; Chiu, G. N. C. A structure–activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities. Eur. J. Med. Chem., 2013, 67, 325-334, DOI: 10.1016/j.ejmech.2013.06.051.
  16. Kalinin, D. V.; Pantsurkin, V. I.; Syropyatov, B. Ya.; Kalinina, S. A.; Rudakova, I. P.; Vakhrin, M. I.; Dolzhenko, A. V.* Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides. Eur. J. Med. Chem., 2013, 63, 144-150, DOI: 10.1016/j.ejmech.2013.02.003.
  17. Kalinin, D. V.; Kalinina, S. A.; Dolzhenko, A. V.* A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide. Heterocycles, 2013, 87(1), 147-154, DOI: 10.3987/COM-12-12601.
  18. Kalinin, D. V.; Kalinina, S. A.; Dolzhenko, A. V.* Synthesis of novel trichloromethyl substituted azolo[1,3,5]triazines. Heterocycles, 2012, 85(10), 2515-2522, DOI: 10.3987/COM-12-12542.
  19. Dolzhenko, A. V.*; Bai, S. Q.; Dolzhenko, A. V.; Chui, W. K. Synthesis and structure of 3,4-dihydropyrido[2’,3’:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines. J. Heterocycl. Chem., 2012, 49(4), 763-767, DOI: 10.1002/jhet.851.
  20. Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Advances in chemistry and biological activity of fluorinated 1,3,5-triazines. In: Triazines: Synthesis, Applications and Toxicity, Eds. R. B. Patel and A. Malhotra, Nova Science Publishers, NY, 2012, pp. 163-200. (ISBN: 978-1-61942-299-5 – print, ISBN: 978-1-61942-307-7 – ebook)
  21. Syropyatov, B. Y.; Kolotova, N. V.; Dolzhenko, A. V. Effects of derivatives of succinic and maleic acids on blood coagulation. Vopr. Biol. Med. Farm. Khim., 2012, (5), 31-36.
  22. Sachdeva, N.; Dolzhenko, A. V.; Chui, W. K. Regioselective synthesis of pyrimido[1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethyl orthoacetate: observation of an unexpected rearrangement. Org. Biomol. Chem., 2012, 10, 4586-4596, DOI: 10.1039/c2ob25195g.

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